San Francisco's famous cable car lines still run up and down those steep hills. There are three lines, two of them go to Fisherman's Wharf, the third runs up Nob Hill to Van Ness, so they are very convenient for tourists.
A good trip would be from Fisherman's Wharf to Chinatown via the Powell-Hyde or Powell-Mason lines.
They are now charging $5 for a one-way ride, which is substantially more than the bus fare which is $1.50, so it's not an economical way to get around the city, but certainly worth a ride or two!
You can also visit the Cable Car Powerhouse and Museum where you can see how the cable-car system works, and learn about its history. It's open 10am to 6pm daily, admission is free!
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